Monday, December 30, 2019

Breast Cancer Essay - 965 Words

Breast cancer exists today as a vicious disease which has multiple facets for killing its host. The largest indicator of survival rate is length of time alive after diagnosis with the disease, and then whether or not the disease has metastasized to a new location in the body. For breast cancer patients, the 5-year survival rate of patients below Stage 4 is 90%. The stages below the 4 stage represent the stages where the breast cancer has not metastasized into other regions of the body. When breast cancer metastasizes into another region of the body, the 5-year survival rate of these individuals drops to 22%. The most common places of metastasis include the brain, liver, and lungs. The goal of studying cell line 231BR is that of†¦show more content†¦Enrichment would not work for this type of analysis as it does not separate the targeted analyte, rather it raises the concentration of the analyte that is involved. Knowing that purification is the type of separation that is to be used, the analyte has to be prepared for analysis by permethylating the glycans preemptively for HPLC, LC-MS, or HILIC. Each respectively stands for High-Power Liquid Chromatography, Liquid Chromatography/Mass Spectrometry, or hydrophilic interaction chromatography. The most common to use is LC-MS as the analyte of interest can be separated and purified for mass spectrometric analysis. Permethylation to understand is a common derivatization method for enhancing ionization efficiency in MS analysis and improves the overall structural stability of the glycan analyte. Later once the analyte is permethylated it is allowed to run through liquid chromatography which separates the analytes by intensity (quantity) and size, which gives the ability to select the analyte of interest. The selection is done with knowledge of what the analyte of interest is before starting the procedure. After the analyte of interest is purified through LC (liquid chromatography) it is taken over to the mass spectrometry machine where the sample is then broken down into the various components. The various components are then broken off one by one slowly until theShow MoreRelatedMale Breast Cancer Essay861 Words   |  4 Pages Breast cancer in males is quite common, yet still many people are unaware of this disease. Often, it can go undiagnosed until the cancer is in the fourth stage. Every year over 2,000 men will be diagnosed, but only 54% will survive. Cancer in men is often overlooked as it is almost 100 times less common in men than women. During a man’s entire lifespan, the risk of having a diagnosis is about one in one-thousand. The most common symptom of this devastating disease are a lump or some swelling. ThisRead More Breast Cancer Essay1204 Words   |  5 Pages BREAST CANCER I) Anatomy of the breast nbsp;nbsp;nbsp;nbsp;nbsp;The breast is a gland designed to make milk. nbsp;nbsp;nbsp;nbsp;nbsp; II) What is breast cancer? nbsp;nbsp;nbsp;nbsp;nbsp;Breast cancer is an abnormal growth of cells. nbsp;nbsp;nbsp;nbsp;nbsp;These abnormal growths are called tumors. Not all tumors are cancerous. nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;Non-cancerous tumors – benign nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;CancerousRead More Breast Cancer Essay1235 Words   |  5 PagesBreast Cancer Cancer is one of the leading causes of death in the United States. There are many different types of cancer that are affecting people all over. Breast Cancer is one of these, and is found in man and women. Over 200,000 women and 1,300 men have been diagnosed with breast cancer this year. One in eight women will detect breast cancer in their lifetime. 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This is how tumors are developed. Our bodies are also equipped with a number of mechanisms that detect and keep such cells in check (1). Breast Cancer (BC), is the most common malignancy in women worldwide, and it is associated with high morbidity and mortality (2). These breast tumors are comprised of phenotypically diverse populations of breast cancer cells (3). However, chemoresistanceRead MoreBreast Cancer Essay1178 Words   |  5 PagesAbstract: Breast cancer is the second most common cancer in women worldwide. The most common type of breast cancer is ductal carcinoma, which arises in cells that lines breast duct. Many imaging techniques are used for the screening and diagnosis, but typically patients are diagnosed at advanced stage only, and the prognosis is associated with early detection. 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Every three minutes a woman is diagnosed: one in eight women will have breast cancer (Walgreens, 2011; Chen, 2010). â€Å"I have to admit, like so many women, I always knew there was a chance. But like so many women, I never thought it would be me. I never thought Id hear those devastating words: You have breast cancer. â€Å"- Debbie Wasserman Schultz, a democratic representative of Florida (2011). Mutations turn genes on and off

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